Published papers - Methodology
- Comets E, Mentré F.
Developing tools to evaluate non-linear mixed effect models : 20 years on the npde adventure.
AAPS Journal, 2021, 23: 75.
Link to PDF of paper
- Cerou M, Lavielle M, Brendel K, Chenel M, Comets E.
Development and performance of npde for the evaluation of time-to-event models.
Journal of Pharmacokinetics and Biopharmaceutics, 2006, 33: 345-67.
Link to PDF of paper
- Nguyen T, Mouksassi MS, Holford N, Al-Huniti N, Freedman I, Hooker AC, John J, Karlsson MO, Mould DR, Pérez Ruixo JJ, Plan EL, Savic R, van Hasselt J, Weber B, Zhou C, Comets E, Mentré F, Model Evaluation Group of the International Society of Pharmacometrics (ISoP) Best Practice Committee.
Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics.
CPT Pharmacometrics and Systems Pharmacology, 2017, 6:87-109.
Link to PDF paper
- Nguyen TH, Comets E, Mentré F.
Extension of NPDE for evaluation of nonlinear mixed effect models in presence of data below the quantification limit with applications to HIV dynamic model.
Journal of Pharmacokinetics and Pharmacodynamics, 2012, 39:499-518.
Link to abstract
- Comets E, Brendel K, Mentré F.
Model evaluation in nonlinear mixed effect models, with applications to pharmacokinetics.
Journal de la Société Francaise de Statistiques, 2010, 151: 106-28.
Link to PDF paper
- Brendel K, Comets E, Laffont C, Mentré F.
Evaluation of different tests based on observations for external model evaluation of population analyses.
Journal of Pharmacokinetics and Pharmacodynamics, 2010, 37: 49-65.
Link to PDF paper
- Comets E, Brendel K, Mentré F.
Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R.
Computer Methods and Programs in Biomedicine, 2008, 90: 154-66.
Link to abstract
- Brendel K, Comets E, Laffont C, Laveille C, Mentré F.
Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide.
Pharmaceutical Research, 2006, 23: 2036-49.
Link to abstract
- Mentré F, Escolano S.
Prediction discrepancies for the evaluation of nonlinear mixed-effects models.
Journal of Pharmacokinetics and Biopharmaceutics, 2006, 33: 345-67.
Link to PDF paper
- Mesnil F, Mentré F, Dubruc C, Thénot J, Mallet A.
Population pharmacokinetics analysis of mizolastine and validation from sparse data on patients using the nonparametric maximum likelihood method.
Journal of Pharmacokinetics and Biopharmaceutics, 1998, 26: 133-61.
Link to abstract
Published papers - Applications
- Comets E, Verstuyft C, Lavielle M, Jaillon P, Becquemont L, Mentré F.
Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters.
European Journal of Clinical Pharmacology, 2007, 63: 437-49.
Link to PDF paper
- Comets E, Ikeda K, Hoff P, Fumoleau P, Wenders J, Tanigawara Y.
Comparison of the pharmacokinetics of S-1, an oral anticancer agent, in Western and Japanese patients.
Journal of Pharmacokinetics and Pharmacodynamics, 2003, 30: 257-83.
Link to abstract
Invited international conferences
- Mentré F, Escolano S.
Validation methods in population pharmacokinetics: a new approach based on predictive distributions with an evaluation by simulation.
IXth Meeting of the Population Approach Group in Europe, Salamanca, Spain, 15-16 june 2000 (oral presentation, abstract 85).
Link to abstract
Other international conferences
- Cerou M, Chenel M, Comets E
Performance of npde for the evaluation of joint model with time to event data.
28th meeting of the Population Approach Group in Europe, Stockholm, Sweden 2019 (oral presentation, abstract 8940).
Link to abstract
- Brendel K, Comets E, Laffont CM, Mentré F.
Normalized prediction distribution error for the evaluation of nonlinear mixed-effects models.
16th Meeting of the Population Approach Group in Europe, Copenhaguen, Denmark, June 14-16, 2007 (oral presentation, abstract 1085).
Link to abstract
- Comets E, Brendel K, Mentré F.
Normalised prediction distribution errors in R: the npde library.
16th Meeting of the Population Approach Group in Europe, Copenhaguen, Denmark, June 14-16, 2007 (poster, abstract 1120).
Link to abstract and PDF of poster
- Brendel K, Comets E, Laffont CM, Mentré F.
Normalised prediction distribution errors for the evaluation of nonlinear mixed-effects models.
9th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand, Singapore, February 13-15, 2007 (oral presentation, abstract 1066).
- Brendel K, Comets E, Laveille C, Lemmenuel-Diot A, Laffont C, Mentré F.
Normalized prediction distribution errors for the evaluation of a population pharmacodynamic model for gliclazide.
5th International Symposium on Measurement and Kinetics of in vivo drug effects, Noordwijkerhout, The Netherlands, April 29, 2006 (poster).
- Brendel K, Comets E, Laveille C, Laffont C, Mentré F.
Metrics based on objective function for external validation of a population pharmacokinetic model.
14th Meeting of the Population Approach Group in Europe, Pamplona, Spain, June 16-17 2005 (poster, abstract 800).
Link to abstract and PDF of poster
- Brendel K, Comets E, Laveille C, Jochemsen R, Mentré F.
Comparison of several prediction errors on concentration for model evaluation.
13th Meeting of the Population Approach Groupe in Europe, Uppsala, Sweden, June 17-18, 2004 (poster, abstract 520).
Link to abstract and PDF of poster
- Mentré F, Escolano S.
Validation of nonlinear mixed-effects models: a new approach based on predictive distributions with an evaluation in population pharmacokinetics.
International Workshop on Goodness-of-fit Tests and Validity of Models, Paris, France, May 29-31, 2000 (oral presentation).
- Mentré F, Escolano S.
Validation of nonlinear mixed-effects models: a new approach based on predictive distributions with an evaluation in population pharmacokinetics.
20th Annual Conference of the International Society for Clinical Biostatistics, Heildelberg, Germany, September 14-17, 1999 (oral presentation).
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