Published papers - methodology

Comets E, Brendel K, Mentré F. Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R, Computer Methods and Programs in Biomedicine, 2008, 90: 154-­66. ­ Link to abstract

Brendel K, Comets E, Laffont C, Laveille C, Mentré F. Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide, Pharmaceutical Research, 2006, 23: 2036-49. ­ Link to abstract

Mentré F, Escolano S. Prediction discrepancies for the evaluation of nonlinear mixed-effects models, Journal of Pharmacokinetics and Biopharmaceutics, 2006, 33: 345-­67. Link to PDF paper

Mesnil F, Mentré F, Dubruc C, Thénot J, Mallet A. Population pharmacokinetics analysis of mizolastine and validation from sparse data on patients using the nonparametric maximum likelihood method. Journal of Pharmacokinetics and Biopharmaceutics, 1998, 26: 133-­61. Link to abstract


Published papers - applications

Comets E, Verstuyft C, Lavielle M, Jaillon P, Becquemont L, Mentré F. Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters. European Journal of Clinical Pharmacology, 2007, 63: 437-­49. Link to PDF of paper


Comets E, Ikeda K, Hoff P, Fumoleau P, Wenders J, Tanigawara Y. Comparison of the pharmacokinetics of S-1, an oral anticancer agent, in Western and Japanese patients. Journal of Pharmacokinetics and Pharmacodynamics, 2003, 30: 257-­83. Link to abstract

Invited international conferences

Mentré F, Escolano S. Validation methods in population pharmacokinetics: a new approach based on predictive distributions with an evaluation by simulation. IXth Meeting of the Population Approach Group in Europe,  Salamanca, Spain, 15-16 june 2000 (oral presentation, abstract 85). Link to abstract

Other international conferences

Brendel K, Comets E, Laffont CM, Mentré F. Normalized prediction distribution error for the evaluation of nonlinear mixed-effects models. 16th Meeting of the Population Approach Group in Europe, Copenhaguen, Denmark, June 14-16, 2007 (oral presentation, abstract 1085). Link to abstract

Comets E, Brendel K, Mentré F. Normalised prediction distribution errors in R: the npde library. 16th Meeting of the Population Approach Group in Europe, Copenhaguen, Denmark, June 14-16, 2007 (poster, abstract 1120). Link to abstract and PDF of poster

Brendel K, Comets E, Laffont CM, Mentré F. Normalised prediction distribution errors for the evaluation of nonlinear mixed-effects models. 9th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand, Singapore, February 13-15, 2007 (oral presentation, abstract 1066).

Brendel K, Comets E, Laveille C, Lemmenuel-Diot A, Laffont C, Mentré F. Normalized prediction distribution errors for the evaluation of a population pharmacodynamic model for gliclazide. 5th International Symposium on Measurement and Kinetics of in vivo drug effects, Noordwijkerhout, The Netherlands, April 29, 2006 (poster).

Brendel K, Comets E, Laveille C, Laffont C,  Mentré F. Metrics based on objective function for external validation of a population pharmacokinetic model. 14th Meeting of the Population Approach Group in Europe, Pamplona, Spain, June 16-17 2005 (poster, abstract 800). Link to abstract and PDF of poster

Brendel K, Comets E, Laveille C, Jochemsen R, Mentré F. Comparison of several prediction errors on concentration for model evaluation. 13th Meeting of the Population Approach Groupe in Europe, Uppsala, Sweden, June 17-18, 2004 (poster, abstract 520). Link to abstract and PDF of poster

Mentré F, Escolano S. Validation of nonlinear mixed-effects models: a new approach based on predictive distributions with an evaluation in population pharmacokinetics. International Workshop on Goodness-of-fit Tests and Validity of Models, Paris, France, May 29-31, 2000 (oral presentation).

Mentré F, Escolano S. Validation of nonlinear mixed-effects models: a new approach based on predictive distributions with an evaluation in population pharmacokinetics. 20th Annual Conference of the International Society for Clinical Biostatistics, Heildelberg, Germany, September 14-17, 1999 (oral presentation).


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©2007 INSERM U738